2,5-Dimethoxy-4-iodoamphetamine (DOI) is a psychedelic drug and a substituted amphetamine.Buy 2,5-Dimethoxy-4-iodoamphetamine(DOI) Online Unlike many other substituted amphetamines, however, it is not primarily a stimulant.DOI has a stereocenter and R-(−)-DOI is the more active stereoisomer. In neuroscience research,-R-(−)-DOI is used as a radioligand and indicator of the presence of 5-HT2A serotonin receptors. DOI’s effects have been compared to LSD, although there are differences that experienced users can distinguish. Besides the longer duration, the trip tends to be more energetic than an LSD trip, with more body load and a different subjective visual experience. The after-effects include residual stimulation and difficulty sleeping, which, depending on the dose, may persist for days.While rare, it is sometimes sold as a substitute for LSD or even sold falsely as LSD, which may be dangerous because DOI does not have the same established safety profile as LSD.DOI is a 5-HT2A, 5-HT2B and 5-HT2C receptor agonist. Buy DOI Online
DOI has been shown to be an extremely potent inhibitor of tumour necrosis factor-alpha inflammation at picomolar concentrations in cell studies. Buy 2,5-Dimethoxy-4-iodoamphetamine(DOI) Online TNF-alpha is an important target for research into degenerative conditions such as rheumatoid arthritis and Alzheimer’s disease, where the disease process involves tissue damage through chronic inflammation. Buy 2,5-Dimethoxy-4-iodoamphetamine(DOI) Online This could make DOI and other 5-HT2A agonists an entirely new area for the development of novel treatments for these conditions. Buy DOI Online
DOI has also been shown to induce rapid growth and reorganization of dendritic spines and synaptic connections with other neurons, processes known to underlie neuroplasticity.DOI was first synthesized by Alexander Shulgin. The radioactive iodine-125 form of DOI for PET imaging was first developed in the lab of David E. Nichols. In January 2007, British police reported that three young men had fallen ill, reportedly, after taking DOI at a rave in Biggleswade, near Milton Keynes, and warned others who had taken it to seek medical attention. This would appear to be the first indication that DOI has found more widespread use as a recreational drug in the UK. The Standard for the Uniform Scheduling of Medicines and Poisons (SUSMP) of Australia does not list DOI as a prohibited substance. In Canada, it’s Listed as an analogue of amphetamine.
The CDSA was updated as a result of the Safe Streets Act changing amphetamines from Schedule to Schedule.DOI is not scheduled in the United States, but it is likely that DOI would be considered an analogue (of DOB), in which case, sales or possession could be prosecuted under the Federal Analogue Act. DOI is occasionally used in animal and in vitro research.Buy 2,5-Dimethoxy-4-iodoamphetamine(DOI) Online